Cerebellar Cortical caused by Dilantin

Cerebellar Cortical Information

Cerebellar Cortical caused by Dilantin 

Cerebellar Cortical causes and symptoms may be linked to Dilantin.

What happens when the cerebellar cortex is damaged depends on the location of the damage.

Science. 1988 Jul 8;241(4862):170-6. Specification of cerebral cortical areas. Rakic P1. 

Abstract: How the immense population of neurons that constitute the human cerebral neocortex is generated from progenitors lining the cerebral ventricle and then distributed to appropriate layers of distinctive cytoarchitectonic areas can be explained by the radial unit hypothesis. 

According to this hypothesis, the ependymal layer of the embryonic cerebral ventricle consists of proliferative units that provide a proto-map of prospective cytoarchitectonic areas. The output of the proliferative units is translated via glial guides to the expanding cortex in the form of ontogenetic columns, whose final number for each area can be modified through interaction with afferent input... 

Dilantin can accumulate in the cerebral cortex over long periods of time which may cause Headaches; Behavioral or personality changes; Dizziness, Damage, and injury.

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Journal of Neurosurgery

October 1999 / Vol. 91 / No. 4 / Pages 588-592 

Clinical Articles Side effects and mortality associated with use of phenytoin for early posttraumatic seizure prophylaxis

Alan M. Haltiner, Ph.D., 

Nancy R. Temkin, Ph.D., 

Sureyya S. Dikmen, Ph.D.

H. Richard Winn, M.D


Object. The goals of this study were to determine if the use of phenytoin to prevent early posttraumatic seizures following head injury was associated with significant adverse side effects and also to determine if the reduction in early posttraumatic seizures after phenytoin administration was associated with a change in mortality rates in head-injured patients.

Reprod Toxicol. 2014 Sep;48:72-80. doi: 10.1016/j.reprotox.2014.04.005. Epub 2014 May 5. 

Developmental neurotoxicity and anticonvulsant drugs: a possible link.

Verrotti A1, Scaparrotta A2, Cofini M1, Chiarelli F2, Tiboni GM3. Author information 

Abstract In utero exposure to antiepileptic drugs (AEDs) may affect neurodevelopment causing postnatal cognitive and behavioral alterations. Phenytoin and phenobarbital may lead to motor and learning dysfunctions in the pre-exposed children. 

These disorders may reflect the interference of these AEDs with the development of hippocampal and cerebellar neurons, as suggested by animal studies. 

Exposure to valproic acid may result in inhibition of neural stem cell proliferation and/or immature neuron migration in the cerebral cortex with consequent increased risk of neurodevelopmental impairment, such as autistic spectrum disorders. 

A central issue in the prevention of AED-mediated developmental effects is the identification of drugs that should be avoided in women of child-bearing potential and during pregnancy.

The aim of this review is to explore the possible link between AEDs and cerebellar neurodevelopmental both in human and in animal studies. The possible mechanisms underlying this association are also discussed. Copyright¬© 2014 Elsevier Inc. All rights reserved. 

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